The GOES-R Series spacecraft bus is three-axis stabilized and designed for 10 years of on-orbit operation preceded by up to five years of on-orbit storage. The satellites are able to operate through periodic station-keeping and momentum adjust maneuvers, which allows for near-continuous instrument observations. Other notable performance elements include vibration isolation for the Earth-pointed optical bench and high-speed spacecraft-to-instrument interfaces designed to maximize science data collection. The cumulative time that GOES-R Series science data collection (including imaging) will be interrupted due to all momentum management, station-keeping, and yaw flip maneuvers is under 120 minutes/year. This is a nearly two orders of magnitude improvement compared to the previous GOES satellites. The spacecraft carries three classifications of instruments: nadir-pointing, solar-pointing, and in-situ.